HLA‐DPB1 DNA POLYMORPHISM IN THE SWISS POPULATION: LINKAGE DISEQUILIBRIUM WITH OTHER HLA LOCI AND POPULATION GENETIC AFFINITIES
Identifieur interne : 000356 ( France/Analysis ); précédent : 000355; suivant : 000357HLA‐DPB1 DNA POLYMORPHISM IN THE SWISS POPULATION: LINKAGE DISEQUILIBRIUM WITH OTHER HLA LOCI AND POPULATION GENETIC AFFINITIES
Auteurs : C. Grundschober [Suisse] ; A. Sanchez-Mazas [France] ; L. Excoffier [France] ; A. Langaney [France] ; M. Jeannet [Suisse] ; J. Tiercy [Suisse]Source :
- International Journal of Immunogenetics [ 1744-3121 ] ; 1994-06.
English descriptors
- Teeft :
- Acute disease, Adjacent loci, Allele, Allelic, Allelic frequencies, Ancestral haplotypes, Balanced selection, Blank alleles, Bone marrow transplantation, Caucasoid populations, Coancestry coefficients, Complement loci, Different continents, Disequilibrium, Dpbl, Dpbl alleles, Dpbl allelic frequencies, Drb1, Drb1 loci, Drbl, Drbl alleles, European journal, European populations, Genetic distances, Genetic diversity, Genetic homogeneity, Genetics, Geographic distances, Haplotype, Haplotype frequencies, Heterozygosity, Heterozygosity level, Heterozygous combinations, Human immunology, Imanishi, Immunology, Important implications, Kimura sasazuki, Limited number, Linkage, Linkage disequilibrium, Locus, Lower level, Main alleles, More polymorphic, Oligonucleotide, Oligonucleotide probes, Oligonucleotide typing, Oligotyping, Original method, Other continents, Other europeans, Other hand, Other loci, Other pairs, Other populations, Oxford university press, Physical distance, Polymerase chain reaction, Polymorphic, Polymorphic frequency, Polymorphic haplotypes, Polymorphism, Population genetics, Positive association, Rapid method, Routine practice, Same frequency, Sample frequency, Sasazuki, Selective neutrality, Significant associations, Significant correlation coefficient, Similar heterozygosity levels, Statistical package ntsys, Swiss individuals, Swiss population, Swiss sample, Tiercy, Tissue anrigens, Tissue antigens, Total disequilibrium, Transplantation, Transplantation proceedings, Tsuji, Unexpected phenotypes.
Abstract
Allelic diversity at the HLA‐DPB1 locus was determined by PCR‐oligotyping in a sample of 125 healthy Swiss individuals. A total of 17 alleles were detected among which four main alleles (DPB 1*0401, *0201, *0301, *0402) reached a cumulative frequency of 74.8%. HLA‐A and ‐B (by serology) and HLA‐DRB1 (by oligotyping) allelic polymorphisms were analysed also. HLA‐B and HLA‐DRB1 loci were highly polymorphic with 25 and 28 alleles respectively and similar heterozygosity levels of 0.93 and 0.92. These two loci were found to be more polymorphic than expected under neutrality, while lower heterozygosity levels were found for HLA‐A (0.87) and DPB1 (0.81) loci. This paper presents also a global comparison of DPB1 allelic frequencies among 15 populations from four continents. As opposed to the DRB1 locus, overall DPB1 is shown to have a lower level of polymorphism and may be considered as neutral in all tested populations. DPB 1 genetic diversity is correlated significantly with geography also, as found previously for DRB1. Two‐ and four‐locus haplotype frequencies were determined and the significance of their linkage disequilibrium tested by an original non‐parametric method. A significant positive linkage disequilibrium was found for 11 A‐B, 16 B‐DRB1, 7 DRB1‐DPB1 and 3 A‐B‐DRB1‐DPB1 haplotypes. The overall linkage disequilibrium between DRB1 and DPB1 was much lower than expected from the physical distance and lower than for A‐B and B‐DRB1 pairs. The implications of these results for bone marrow transplantation and for the evolution of HLA loci are discussed.
Url:
DOI: 10.1111/j.1744-313X.1994.tb00186.x
Affiliations:
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Grundschober</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Unité? Immunologie de Transplantation, Division ? Immunologie et ? Allergologie, Hôpital Cantonal Universitaire, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Azas, A" sort="Sanchez Azas, A" uniqKey="Sanchez Azas A" first="A." last="Sanchez-Mazas">A. Sanchez-Mazas</name><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génétique et Biométrie, Département ? Anthropologie et ? Ecologie, Université de Genève, Geneva, Switzerland, and URA49 CNRS Museum, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université de Genève</orgName></affiliation></author><author><name sortKey="Excoffier, L" sort="Excoffier, L" uniqKey="Excoffier L" first="L." last="Excoffier">L. Excoffier</name><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génétique et Biométrie, Département ? Anthropologie et ? Ecologie, Université de Genève, Geneva, Switzerland, and URA49 CNRS Museum, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université de Genève</orgName></affiliation></author><author><name sortKey="Langaney, A" sort="Langaney, A" uniqKey="Langaney A" first="A." last="Langaney">A. Langaney</name><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génétique et Biométrie, Département ? Anthropologie et ? Ecologie, Université de Genève, Geneva, Switzerland, and URA49 CNRS Museum, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université de Genève</orgName></affiliation></author><author><name sortKey="Jeannet, M" sort="Jeannet, M" uniqKey="Jeannet M" first="M." last="Jeannet">M. Jeannet</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Unité? Immunologie de Transplantation, Division ? Immunologie et ? Allergologie, Hôpital Cantonal Universitaire, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Tiercy, J" sort="Tiercy, J" uniqKey="Tiercy J" first="J." last="Tiercy">J. Tiercy</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Unité? Immunologie de Transplantation, Division ? Immunologie et ? Allergologie, Hôpital Cantonal Universitaire, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Correspondence address: Dr J.‐M. Tiercy, Unité?Immunologie de Transplantation, Laboratory 8252, Centre Médical Universitaire, 1 rue Michel Servet, 1211 Genève 4</wicri:regionArea><wicri:noRegion>1211 Genève 4</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Immunogenetics</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF IMMUNOGENETICS</title><idno type="ISSN">1744-3121</idno><idno type="eISSN">1744-313X</idno><imprint><biblScope unit="vol">21</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="143">143</biblScope><biblScope unit="page" to="157">157</biblScope><biblScope unit="page-count">15</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1994-06">1994-06</date></imprint><idno type="ISSN">1744-3121</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1744-3121</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute disease</term><term>Adjacent loci</term><term>Allele</term><term>Allelic</term><term>Allelic frequencies</term><term>Ancestral haplotypes</term><term>Balanced selection</term><term>Blank alleles</term><term>Bone marrow transplantation</term><term>Caucasoid populations</term><term>Coancestry coefficients</term><term>Complement loci</term><term>Different continents</term><term>Disequilibrium</term><term>Dpbl</term><term>Dpbl alleles</term><term>Dpbl allelic frequencies</term><term>Drb1</term><term>Drb1 loci</term><term>Drbl</term><term>Drbl alleles</term><term>European journal</term><term>European populations</term><term>Genetic distances</term><term>Genetic diversity</term><term>Genetic homogeneity</term><term>Genetics</term><term>Geographic distances</term><term>Haplotype</term><term>Haplotype frequencies</term><term>Heterozygosity</term><term>Heterozygosity level</term><term>Heterozygous combinations</term><term>Human immunology</term><term>Imanishi</term><term>Immunology</term><term>Important implications</term><term>Kimura sasazuki</term><term>Limited number</term><term>Linkage</term><term>Linkage disequilibrium</term><term>Locus</term><term>Lower level</term><term>Main alleles</term><term>More polymorphic</term><term>Oligonucleotide</term><term>Oligonucleotide probes</term><term>Oligonucleotide typing</term><term>Oligotyping</term><term>Original method</term><term>Other continents</term><term>Other europeans</term><term>Other hand</term><term>Other loci</term><term>Other pairs</term><term>Other populations</term><term>Oxford university press</term><term>Physical distance</term><term>Polymerase chain reaction</term><term>Polymorphic</term><term>Polymorphic frequency</term><term>Polymorphic haplotypes</term><term>Polymorphism</term><term>Population genetics</term><term>Positive association</term><term>Rapid method</term><term>Routine practice</term><term>Same frequency</term><term>Sample frequency</term><term>Sasazuki</term><term>Selective neutrality</term><term>Significant associations</term><term>Significant correlation coefficient</term><term>Similar heterozygosity levels</term><term>Statistical package ntsys</term><term>Swiss individuals</term><term>Swiss population</term><term>Swiss sample</term><term>Tiercy</term><term>Tissue anrigens</term><term>Tissue antigens</term><term>Total disequilibrium</term><term>Transplantation</term><term>Transplantation proceedings</term><term>Tsuji</term><term>Unexpected phenotypes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Allelic diversity at the HLA‐DPB1 locus was determined by PCR‐oligotyping in a sample of 125 healthy Swiss individuals. A total of 17 alleles were detected among which four main alleles (DPB 1*0401, *0201, *0301, *0402) reached a cumulative frequency of 74.8%. HLA‐A and ‐B (by serology) and HLA‐DRB1 (by oligotyping) allelic polymorphisms were analysed also. HLA‐B and HLA‐DRB1 loci were highly polymorphic with 25 and 28 alleles respectively and similar heterozygosity levels of 0.93 and 0.92. These two loci were found to be more polymorphic than expected under neutrality, while lower heterozygosity levels were found for HLA‐A (0.87) and DPB1 (0.81) loci. This paper presents also a global comparison of DPB1 allelic frequencies among 15 populations from four continents. As opposed to the DRB1 locus, overall DPB1 is shown to have a lower level of polymorphism and may be considered as neutral in all tested populations. DPB 1 genetic diversity is correlated significantly with geography also, as found previously for DRB1. Two‐ and four‐locus haplotype frequencies were determined and the significance of their linkage disequilibrium tested by an original non‐parametric method. A significant positive linkage disequilibrium was found for 11 A‐B, 16 B‐DRB1, 7 DRB1‐DPB1 and 3 A‐B‐DRB1‐DPB1 haplotypes. The overall linkage disequilibrium between DRB1 and DPB1 was much lower than expected from the physical distance and lower than for A‐B and B‐DRB1 pairs. The implications of these results for bone marrow transplantation and for the evolution of HLA loci are discussed.</div></front></TEI><affiliations><list><country><li>France</li><li>Suisse</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université de Genève</li></orgName></list><tree><country name="Suisse"><noRegion><name sortKey="Grundschober, C" sort="Grundschober, C" uniqKey="Grundschober C" first="C." last="Grundschober">C. Grundschober</name></noRegion><name sortKey="Jeannet, M" sort="Jeannet, M" uniqKey="Jeannet M" first="M." last="Jeannet">M. Jeannet</name><name sortKey="Tiercy, J" sort="Tiercy, J" uniqKey="Tiercy J" first="J." last="Tiercy">J. Tiercy</name><name sortKey="Tiercy, J" sort="Tiercy, J" uniqKey="Tiercy J" first="J." last="Tiercy">J. Tiercy</name></country><country name="France"><region name="Île-de-France"><name sortKey="Sanchez Azas, A" sort="Sanchez Azas, A" uniqKey="Sanchez Azas A" first="A." last="Sanchez-Mazas">A. Sanchez-Mazas</name></region><name sortKey="Excoffier, L" sort="Excoffier, L" uniqKey="Excoffier L" first="L." last="Excoffier">L. Excoffier</name><name sortKey="Langaney, A" sort="Langaney, A" uniqKey="Langaney A" first="A." last="Langaney">A. Langaney</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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